In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
نویسندگان
چکیده
منابع مشابه
In vitro and in vivo mRNA delivery using lipid-enveloped pH-responsive polymer nanoparticles.
Biodegradable core--shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption, while the lipid surface layer was selected to minimize toxicity of the polycation core. Messenge...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2011
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp100390w